Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis

Al-Ani, Imad Matloub Dally and Al-Murayati, Hayder Y. and Salman, Mohammad O. and Ghani, Hameed M. (2011) Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis. Biomedical Research, 22 (4). pp. 425-430. ISSN 0970938X

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Abstract

Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evi-dence of renal damage. The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the me-dulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capa-ble of producing chronic pyelonephritis in the rats after a single reflux challenge.

Item Type:	Article (Journal)
Additional Information:	5849/10724
Uncontrolled Keywords:	Kidney, Proteus mirabilis, Pyelonephritis, Rats, Urinary tract.
Subjects:	Q Science > QM Human anatomy Q Science > QR Microbiology R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited:	20 Dec 2011 10:24
Last Modified:	18 Dec 2015 10:45
URI:	http://irep.iium.edu.my/id/eprint/10724

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