Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review

Mohd Nisfu, Farah Ratulfazira and Roslan, Madihah and Mohd Arifin, Siti Roshaidai and Zainuddin, Norafiza (2023) Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review. Journal of Health and Translational Medicine, 26 (1). pp. 38-48. ISSN 1823-7339 E-ISSN 2289-392X

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Abstract

Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (NVP), which can lead to extreme dehydration, significant weight loss, and electrolyte and metabolic imbalances. Importantly, early identification of HG symptoms can help to reduce its severity and prevent complications. Although HG is associated with many adverse maternal and fetal outcomes, there is limited understanding of the risk factors. This review provides current data on genetic and maternal factors that are linked to HG. All observational studies published in English that investigated the genetic or maternal factors associated with HG from 2011 until 2021 were systematically searched using the PubMed, Scopus, and ProQuest electronic databases. A total of 1462 citation titles was identified, of which 47 potentially relevant abstracts were screened. Of those, 15 studies met the inclusion and exclusion criteria. The genetic variants in the ryanodine receptor 2 gene (RYR2), growth differentiation factor-15 (GDF15), and protein-coding insulin-like growth factor-binding protein 7 (IGFBP7) were found to be associated with HG. On the other hand, several potential maternal factors contributing to the onset of HG were age, Helicobacter pylori infection, body mass index (BMI) status, a history of HG in a previous pregnancy, carrying a female fetus, high serotonin levels, and reproductive factors. In view of the lack of strength of the overall evidence for risk factors related to HG, it is first imperative to establish a precise definition for HG in a diverse study population. Nevertheless, to conclude, this review was able to provide current data on genetic and maternal factors that are associated with HG.

Item Type:	Article (Review)
Uncontrolled Keywords:	Hyperemesis Gravidarum, Nausea, Vomiting, Pregnancy, Risk Factors, Genetic
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RG Gynecology and obstetrics R Medicine > RG Gynecology and obstetrics > RG551 Pregnancy
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Nursing Kulliyyah of Nursing > Department of Special Care Nursing
Depositing User:	Dr. Norafiza Zainuddin
Date Deposited:	03 Apr 2023 12:45
Last Modified:	20 Jun 2024 12:00
URI:	http://irep.iium.edu.my/id/eprint/104073

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• Genetic and maternal factors in Hyperemesis Gravidarum: A systematic review. (deposited UNSPECIFIED)
  • Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review. (deposited 31 Jan 2023 16:05)
    • Genetic and maternal factors in Hyperemesis Gravidarum: a systematic review. (deposited 03 Apr 2023 12:45) [Currently Displayed]

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