Menthol and fatty acid-based hydrophobic deep eutectic solvents as media for enzyme activation

Elgharbawy, Amal A.M. and Syed Putra, Sharifah Shahira and Warsi Khan, Huma and Azmi, Nor Azrini Nadiha and Abdullah Sani, Muhamad Shirwan and Ab llah, Nazurah and Hayyan, Adeeb and Jewaratnam, Jegalakshimi and Basirun, Wan Jefrey (2023) Menthol and fatty acid-based hydrophobic deep eutectic solvents as media for enzyme activation. Processes, 11 (2). pp. 1-21. E-ISSN 2227-9717

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Abstract

This research aims to provide insights into the biological efficacy of a newly formed hydrophobic deep eutectic solvent (DES). A DES based on menthol was successfully synthesized with fatty acids. The DESs’ properties as enzyme activators were examined against a neat counterpart. The menthol:decanoic acid (1:1) combination showed improved thermal stability, strong catalytic activity, and reusability for up to four subsequent cycles under ideal conditions (pH 7.0, 40 ◦C for 2 h). The hydrophobic DES replaced hexane in ester synthesis, where RNL@DES5 showed better fatty acid conversion compared to neat RNL. This study demonstrated promising applications of hydrophobic DESs in non-aqueous organic reactions.

Item Type:	Article (Journal)
Uncontrolled Keywords:	fatty acid; natural deep eutectic solvents; hydrophobic agent; enzyme kinetics; hydrogen-bonding
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Dr AMAL ELGHARBAWY
Date Deposited:	14 Feb 2023 17:41
Last Modified:	27 Jul 2023 16:14
URI:	http://irep.iium.edu.my/id/eprint/103693

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