Qualitative physical assessment on the effects of salt on potential hydrogels used in nanoparticle drug delivery

Abd Moulud, Ummi Nadiahtulnajiah and Mohamed Suffian, Izzat Fahimuddin and Zakaria, Siti Fatimah and Hamzah, Nurasyikin and Che Othman, Siti Fairuz (2022) Qualitative physical assessment on the effects of salt on potential hydrogels used in nanoparticle drug delivery. Revelation and Science, 12 (2). pp. 79-94. E-ISSN 2229-9947

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Abstract

The prevalence of oral cancer cases worldwide has urged scientists to revise topical drug formulations meant for oral application improving drug locality. This alternative treatment helps to minimise the side effects from the current available treatment. The physicochemical properties of the material need to be assessed when designing a new topical drug. Therefore, this paper aims in developing formulation and characterise hydrogels with the addition of different salt concentrations. In this project, the hydrogels studied are iota-carrageenan and kappa-carrageenan. As salt is the common ingredient used in drug formulation, the effects of salt on the physical properties of carrageenan are studied. Each concentration of the carrageenan is formulated with four different concentrations of salt at 0.5%, 1.0%, 1.5%, and 2.0%. The pH of the solution is maintained at pH 7. The results show that both concentrations of kappa-carrageenan are not suitable to be used as a carrier for nano-topical drugs due to their hard and rigid texture. Based on the physical properties, the suitable formulation for nano-matrix would be the 0.5% iota-carrageenan added with 1.5% and 2.0% NaCl, as well as the 1.0% iota-carrageenan added with 0.5% NaCl.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Oral cancer, drug delivery, nanotechnology, carrageenan, salt
Subjects:	Q Science > QH Natural history > QH301 Biology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr Siti Fairuz Che Othman
Date Deposited:	13 Feb 2023 16:36
Last Modified:	13 Feb 2023 16:37
URI:	http://irep.iium.edu.my/id/eprint/103679

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