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The impact of anticancer drugs on the ocular surface

Chiang, Jeremy Chung Bo and Zahari, Ilyanoon and Markoulli, Maria and Krishnan, Arun. V and Park, Susanna B. and Semmler, Annalese and Goldstein, David and Edwards, Katie (2020) The impact of anticancer drugs on the ocular surface. Ocular Surface, 18 (3). pp. 403-417. ISSN 1542-0124

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Abstract

Cancer is a global health problem and is one of the leading causes of death worldwide. Pleasingly, the rate of survival has improved and continues in an upward trend mainly due to better diagnosis and treatment modalities. In particular, the development of anticancer drugs including cytotoxic chemotherapy, hormonal agents and targeted therapies have provided the most effective treatment options in combatting cancerous cells. However, the antineoplastic mechanisms of these drugs can also lead to undesirable systemic and ocular side effects resulting from cytotoxicity, inflammation and neurotoxicity. While survival rates are projected to increase with time, the number of patients presenting with these side effects that can substantially impact quality of life will also rise. The current paper reviews the ocular surface and adnexal side effects of anticancer drugs, the appropriate management and possible interactions between drugs for ocular surface pathology treatment and the anticancer drugs

Item Type: Article (Review)
Additional Information: 6056/87831
Uncontrolled Keywords: Anticancer drugs, Chemotherapy, Drug interactions, Hormonal agents, Ocular adnexa, Ocular side effects, Ocular surface, Targeted therapies
Subjects: R Medicine > RE Ophthalmology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Optometry and Visual Science
Depositing User: Mrs Suhani Saarani
Date Deposited: 14 Jan 2021 18:01
Last Modified: 14 Jan 2021 18:01
URI: http://irep.iium.edu.my/id/eprint/87831

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