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Development of biodegradable cosmetic patch using a polylactic acid/phycocyanin–alginate composite

Adli, Sarah Amalina and Ali, Fathilah and Azmi, Azlin Suhaida and Anuar, Hazleen and Mohd Nasir, Nur Aimi and Hasham, Rosnani and Hafiz Idris, Mohamad Khairul (2020) Development of biodegradable cosmetic patch using a polylactic acid/phycocyanin–alginate composite. Polymers, 12 (8). pp. 1-11. E-ISSN 2073-4360

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The usage of non-degradable polymer as the main matrix for a cosmetic patch raises concern, as it can cause environmental pollution when discarded in landfill. Thus, biodegradable polylactic acid (PLA) was chosen in this study, as PLA has non-toxic properties and similar mechanical properties to conventional plastic materials. An active ingredient in a cosmetic patch serves the purpose of providing beneficial ingredients to the skin; therefore, phycocyanin, an extract from spirulina, was chosen, as it possesses antioxidant and anti-inflammatory properties. Alginate was also incorporated with the phycocyanin for fabrication onto the PLA matrix. A preliminary study was first carried out to identify the antioxidant properties and cytotoxic effect of the phycocyanin on skin cells. It was observed that phycocyanin had no cytotoxic effect on the skin and showed good antioxidant activity. PLA/phycocyanin–alginate composite was fabricated using a solvent casting method, and optimization of preparation conditions (phycocyanin/alginate ratio, stirring time, and temperature) were carried out using the one-factor-at-a-time (OFAT) method with responses of elongation at break and releasing properties. Attenuated total reflectance (ATR)–FTIR analysis was also conducted to further analyze the functional group of the composites. Surface morphologies were observed for samples before and after the releasing test. From the analyses conducted, PLA/phycocyanin–alginate composite prepared at a phycocyanin/alginate ratio of 40/60 for 20 h at 20 °C gave the best properties in terms of flexibility of film and releasing properties of phycocyanin.

Item Type: Article (Journal)
Additional Information: 5439/81891
Uncontrolled Keywords: patches; cosmetic, phycocyanin, PLA, spirulina extract, alginate.
Subjects: T Technology > T Technology (General)
T Technology > TP Chemical technology > TP1080 Polymers, plastics and their manufacture
T Technology > TP Chemical technology > TP248.13 Biotechnology
T Technology > TS Manufactures
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering
Kulliyyah of Engineering > Department of Biotechnology Engineering
Kulliyyah of Engineering > Department of Manufacturing and Materials Engineering
Depositing User: Dr Fathilah Ali
Date Deposited: 30 Jul 2020 10:50
Last Modified: 29 Dec 2020 14:49
URI: http://irep.iium.edu.my/id/eprint/81891

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