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Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models

Ramli, Nurul Syahida and Baharun, Bibi Nur Bazlini and Ismail, Azlini and Abu Bakar, Nor Hidayah and Noordin, Liza and Wan Ahmad, Wan Amir Nizam (2019) Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models. Annals of Microscopy, 18. pp. 4-10. ISSN 0219-2209

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Abstract

The spontaneously hypertensive rat (SHR) has been well established as a suitable model for hypertension research, but little is known about the morphology of hypertensive vascular remodeling in this model. The present study was designed to investigate the structural changes of blood vessels in 6 months aged SHR in comparison to their corresponding model, Wistar Kyoto rats (WKY). The study utilised 12 male rats; which were equally divided into 6 SHR and 6 WKY. During dissection, thoracic aorta was harvested for histological examination. To evaluate the morphological appearance of SHR and WKY, hematoxylin and eosin (H&E) stain was done. Whereas Scanning electron microscopy was applied to view the ultrastructure of the vessel. The result shows that the aorta histology of WKY looks normal; depicted by showing smooth intima with a single layer of endothelial cells. In contrast with SHR, the structure was slightly distorted and thicker intima observed; suggesting vascular remodeling has occurred.

Item Type: Article (Journal)
Additional Information: 7407/72699
Uncontrolled Keywords: Spontaneously Hypertensive Rats, SHR, hypertension, aorta, salam, serai kayu, antihypertensive, cardiovascular
Subjects: R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry > Fundamental Dental and Medical Sciences
Kulliyyah of Dentistry
Depositing User: DR. AZLINI ISMAIL
Date Deposited: 19 Jun 2019 10:35
Last Modified: 19 Jun 2019 10:35
URI: http://irep.iium.edu.my/id/eprint/72699

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