IIUM Repository

Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility

Samsudin, Nurhusna and Hashim, Yumi Zuhanis Has-Yun and Arifin, Mohd Azmir and Mel, Maizirwan and Mohd. Salleh, Hamzah (2018) Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand.

[img] PDF (print proceeding) - Published Version
Restricted to Registered users only

Download (396kB) | Request a copy
[img] PDF (e-proceeding) - Published Version
Restricted to Registered users only

Download (2MB) | Request a copy

Abstract

Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum cell number of 3.90 x 105 cells/ml as compared to cell proliferation on UV/O3 treated porous PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 3774/66282
Uncontrolled Keywords: Halal, porous microcarrier, UV/O3, treatment, microcarrier cell culture
Subjects: Q Science > Q Science (General)
T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): International Institute for Halal Research and Training (INHART)
Kulliyyah of Engineering
Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: DR YUMI ZUHANIS HAS-YUN HASHIM
Date Deposited: 02 Oct 2018 16:49
Last Modified: 30 Jan 2020 12:19
URI: http://irep.iium.edu.my/id/eprint/66282

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year