E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53

Ma, Kaiwen and Araki, Keigo and Arief Ichwan, Solachuddin Jauhari (2003) E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53. Molecular Cancer Research, 1 (6). pp. 438-444. ISSN 1541-7786

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Abstract

E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/ DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/ DRIL1 gene. E2FBP1/DRIL1was induced by p53 and upregulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/ DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53.

Item Type:	Article (Journal)
Additional Information:	5731/28001
Uncontrolled Keywords:	E2FBP1/DRIL1,AT-Rich interaction domain-family transcription factor,p53
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry
Depositing User:	Dr. Solachuddin J.A. Ichwan
Date Deposited:	31 Dec 2012 07:58
Last Modified:	14 Feb 2013 05:19
URI:	http://irep.iium.edu.my/id/eprint/28001

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