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Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review

Ismawi, Hidayatul Radziah and Zulkiflee, Khodijah and Yusoff Azmi Merican, Yusoff Sharizal and Mohd. Zainudin, Maizura and Abd. Fuaat, Azliana and Zainal Abidin, Fadhilah (2025) Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review. Malaysian Journal of Medicine and Health Sciences, 21 (5). pp. 302-309. ISSN 1675-8544 E-ISSN 2636-9346

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Abstract

Understanding ultrastructural changes in vascular tissue provides critical insights into the pathophysiology of hyper-tension, a leading global cause of mortality. This scoping review aims to offer a comprehensive overview of vascular ultrastructural changes in hypertensive rodent models over the past 15 years. Following the Arksey and O’Malley protocol, we conducted a scoping review of relevant literature. This involved defining research questions, identifying and selecting pertinent studies, data extraction, synthesis, and reporting. Searches encompassed Google Scholar, PubMed, Scopus, and Science Direct. Thirty studies were included, showcasing diverse methodologies, objectives, and findings. These studies investigated various hypertensive models, different vessels, and multiple quantitative, semi-quantitative, and qualitative parameters of vascular ultrastructure, along with different intervention strategies. This review provides a synthesis of existing knowledge on vascular ultrastructural changes in hypertensive rodent models and discusses relevance of rodent models to human hypertension, functional implications of ultrastructural changes and pharmacological interventions targeting these changes thus serving as a resource for researchers studying hypertension pathophysiology to identify therapeutic targets or assess novel interventions.

Item Type: Article (Journal)
Uncontrolled Keywords: Hypertension, Ultrastructure, Rodent, Animal Models, Review
Subjects: Q Science > QM Human anatomy
R Medicine > R Medicine (General)
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Dr Hidayatul Radziah Ismawi
Date Deposited: 14 Oct 2025 15:54
Last Modified: 14 Oct 2025 15:54
URI: http://irep.iium.edu.my/id/eprint/123706

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