Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability

Harimurti, Sabtanti and Febriyani, Dwi and Sukamdi, Dyani Primasari and Widada, Hari and Amid, Azura (2024) Development of Moringa Leave Extract Nanoemulsions: effect of ethanol concentration and sonication toward the stability. In: 4th International Conference on Pharmaceutical Updates (ICPU 2024), 7th-8th August 2024, Yogyakarta, Indonesia.

PDF - Published Version Restricted to Registered users only Download (454kB) | Request a copy

Abstract

Preparation of serum in the form of extract nanoemulsions allows effective delivery of active ingredients to the skin due to the more stable nanoemulsions, lower viscosity, transparent visual aspects, and high surface area caused by the small globule size. This study aims to obtain an optimal 96% ethanol concentration and sonication time in forming stable nanoemulsions at temperatures of 4° and 40°C with an active ingredient of moringa leaf extracts. The experiment was performed in four sets of 96% ethanol concentration (5%, 10%, 15%, and 20%) and three sonication periods (30, 60, and 90 minutes). The freeze-and-thaw method was utilized to evaluate the stability of the nanoemulsions. The analysis unveiled that a 96% ethanol concentration of 10% and a sonication time of 46 minutes was the most appropriate formula, generating a particle size of 30.49 nm with a volume of 73.35%. At the same time, the stability test of the preparation revealed that storage time significantly affected the pH response. However, it did not significantly affect the viscosity response.

Item Type:	Proceeding Paper (Plenary Papers)
Additional Information:	3688/116015 - not yet indexed in SCOPUS - WSS 21112024
Uncontrolled Keywords:	Moringa leaf extract; nanoemulsion; stability test; optimization; sonication time.
Subjects:	T Technology > TP Chemical technology T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Mrs. Wan Salwati Wan Salleh
Date Deposited:	21 Nov 2024 13:45
Last Modified:	21 Nov 2024 13:45
URI:	http://irep.iium.edu.my/id/eprint/116015

Actions (login required)

View Item