Effect of incorporating cellulose nanofibers and lemongrass essential oil in polyvinyl alcohol-polyethylene glycol/glycerin hydrogel for wound dressing

Jafri, Nur Huda Syazwani and Jimat, Dzun Noraini and Wan Nawawi, Wan Mohd Fazli and Ahmad Nor, Yusilawati and Amid, Azura (2024) Effect of incorporating cellulose nanofibers and lemongrass essential oil in polyvinyl alcohol-polyethylene glycol/glycerin hydrogel for wound dressing. IIUM Engineering Journal, 25 (2). pp. 99-115. ISSN 1511-788X E-ISSN 2289-7860

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Abstract

Hydrogels are attracting increased interest as wound dressings due to their biomimetic properties, which create a moist environment conducive to natural wound healing. In this study, a PVA-PEG/gly-CNF-LG hydrogel incorporating cellulose nanofibers (CNF) and lemongrass essential oil (LG) into the polyvinyl alcohol-polyethylene glycol/glycerin (PVA-PEG/gly) hydrogel via the freeze-thaw method was developed. The addition of CNFs and LG aimed to improve the physicochemical and antibacterial aspects of the hydrogel. Optimal hydrogel composition, determined through response surface methodology (RSM) and central composite design (CCD), consisted of 3.5% (w/v) CNFs and 3% (v/v) LG concentrations, resulting in an optimal moisture retention capability (MRC) of 37.69 ± 0.54%. The optimized PVA-PEG/gly-CNF-LG demonstrated impressive characteristics: a swelling capacity of 176.89 ± 1.56%, a gel fraction of 78.89 ± 0.42%, and a porosity of 47.51 ± 0.53%. FESEM images revealed the relatively porous nature of PVA-PEG/gly-CNF-LG hydrogels. Furthermore, the hydrogel exhibited excellent resistance against S. aureus and B. subtilis bacteria, along with notable tensile properties of 1.44 MPa. These findings underscore the promising attributes of the PVA-PEG/gly-CNF-LG hydrogel, positioning it as a versatile and effective wound healing dressing with significant antimicrobial properties.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Cellulose Nanofibers, Glycerin, Lemongrass essential oil, Polyethylene glycol, Polyvinyl alcohol
Subjects:	T Technology > T Technology (General) T Technology > TP Chemical technology > TP1080 Polymers, plastics and their manufacture T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering International Institute for Halal Research and Training (INHART) Kulliyyah of Engineering
Depositing User:	Dr Dzun Noraini Jimat
Date Deposited:	23 Jul 2024 16:20
Last Modified:	23 Jul 2024 16:20
URI:	http://irep.iium.edu.my/id/eprint/113305

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