The role of podoplanin inhibitors in controlling oral cancer progression

Engku Ngah Sayuddin, Engku Nasiha and Bakhtiar, Muhammad Taher and Arzmi, Mohd Hafiz and Burhanudin, Nor Aszlitah and Rostam, Muhamad Ashraf (2023) The role of podoplanin inhibitors in controlling oral cancer progression. Archives of Oral Biology, 157. pp. 1-7. ISSN 0003-9969 E-ISSN 1879-1506

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Abstract

Objective: In this article, we review the current studies on the role of podoplanin in oral cancer and the potential application of podoplanin inhibitors as a therapeutic agent for oral cancer. Design: The narrative review approach was conducted, providing a comprehensive perspective of related literature. Publications addressing podoplanin and its inhibitors in the context of oral cancer were retrieved from PubMed and Scopus databases. Results: Podoplanin has emerged as a biomarker and therapeutic agent for oral cancer. Numerous studies have reported high podoplanin expression in oral cancer and pre-cancerous lesions compared to normal cells. A specific inhibitor targeting podoplanin may have the potential to prevent oral carcinogenesis via interfering with the pathway of cancerous cells involved in cell proliferation and metastasis. Antibodies, chimeric antigen receptor (CAR)-T cells, cancer-specific mAb (CasMab), synthetic molecules, and lectins are among the materials used as anticancer agents targeting podoplanin. Plant-derived lectins appear to demonstrate a unique advantage against alternative candidates. Conclusions: The use of podoplanin inhibitors in place of existing therapeutic approaches could be a promising and novel approach to the prevention and treatment of oral cancer. Nevertheless, further research is required to investigate the practical application of such inhibitors.

Item Type:	Article (Review)
Uncontrolled Keywords:	Oral cancer OSCC Podoplanin Podoplanin inhibitor Lectin
Subjects:	R Medicine > RK Dentistry R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry > Department of Oral Maxillofacial Surgery and Oral Diagnosis Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhamad Ashraf Rostam
Date Deposited:	15 Nov 2023 08:34
Last Modified:	08 Jan 2024 13:29
URI:	http://irep.iium.edu.my/id/eprint/108063

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