Tariq, Ayesha and Bhatti, Zohra and Khan, Amer. H. and Laghari, Madeeha and Talpur, Bandeh Ali and Aamir, Muhammad and Hussain, Khalid (2026) Diabetes mellitus duration and major adverse cardiovascular events following percutaneous coronary intervention: a prospective cohort study. International Journal of Vascular Medicine, 2026 (1). pp. 1-12. ISSN 2090-2824 E-ISSN 2090-2832
|
PDF
- Published Version
Download (1MB) | Preview |
|
|
PDF
- Supplemental Material
Download (275kB) | Preview |
|
|
PDF
- Supplemental Material
Download (136kB) | Preview |
Abstract
Objective: This study is aimed at evaluating the impact of Type 2 diabetes mellitus (T2DM) duration on major adverse cardiovascular events (MACEs) after percutaneous coronary intervention (PCI). Methods: A single-center prospective cohort study was conducted in which 465 T2DM patients undergoing PCI and completing the 1-year follow-up were enrolled. Patients were divided into three groups based on duration of DM: < 5 years, 5–10 years, and > 10 years. The primary endpoint was MACE, a composite of nonfatal myocardial infarction (MI), stroke, coronary artery bypass grafting (CABG), repeat PCI, and mortality. Results: The incidence of MACE increased progressively with longer diabetes duration: 3.7% (< 5 years), 8.1% (5–10 years), and 13.9% (> 10 years), with particularly higher rates of stroke (0.6%–3.0%) and repeat PCI (1.8%–6.0%) among T2DM patients after PCI. The Kaplan–Meier analysis demonstrated a clear stepwise rise in cumulative MACE incidence over 12 months, with the highest event rates observed in patients with diabetes for more than 10 years (log-rank p < 0.004). Consistently, Cox proportional hazards models showed significantly elevated risk compared with the < 5-year group, with adjusted hazard ratios of 3.16 (95% CI: 1.06–9.47, p = 0.039) for 5–10 years and 4.37 (95% CI: 1.59–12.01, p = 0.004) for > 10 years. Conclusion: Patients with longer duration (> 10 years) of T2DM had the highest incidence and hazard of adverse cardiovascular events compared to shorter duration (< 5 years and 5–10 years). These results suggest that targeted preventive strategies and closer post-PCI monitoring are essential for patients with prolonged diabetes duration.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | duration of diabetes mellitus; major adverse cardiovascular events; percutaneous coronary intervention; Type 2 diabetes mellitus |
| Subjects: | R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy > Department of Pharmacy Practice |
| Depositing User: | Dr Zohra Bhatti |
| Date Deposited: | 14 Sep 2026 15:32 |
| Last Update: | 14 Sep 2026 15:32 |
| Queue Number: | 2026-09-Q5060 |
| URI: | http://irep.iium.edu.my/id/eprint/131198 |
| Indexed In: | WOS and SCOPUS, Google Scholar |
Actions (login required)
 |
View Item |