Mohamad Ansor, Nurhuda and Suppiah, Pavithra and Suhaimi, Nur Nadhirah and Mohd Zaki, Syazwani (2026) Ulam raja–infused PVA–chitosan hydrogel for localised treatment of colorectal cancer. In: Monograf - Inovasi Alam Melayu antarabangsa 2025. Institut Pemikiran Dan Kepimpinan Melayu,Universiti Teknologi MARA, Selangor, Malaysia, pp. 148-154.
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Abstract
Conventional chemotherapy for colorectal cancer, while effective, is often limited by systemic toxicity and lack of specificity. To address this challenge, we developed a Ulam raja (Cosmos caudatus)-infused polyvinyl alcohol (PVA)-chitosan hydrogel designed to deliver localised anticancer effects through sustained release of plant-derived bioactive compounds. The hydrogel was prepared by dissolving PVA and chitosan in distilled water and mixing them thoroughly with a magnetic stirrer until a homogeneous solution was obtained. This solution was then incorporated with ulam raja extract, known for its flavonoid-rich profile with antiproliferative and antimigratory effects against colorectal cancer cells. Morphological structure, physicochemical characteristics and mechanical properties were examined to establish a suitable Ulam raja-infused PVA-chitosan hydrogel as a delivery platform for bioactive substances. Unlike conventional drug delivery systems, this innovation integrates natural anticancer agents with a biodegradable and cost-effective delivery matrix, enabling sitespecific therapeutic action without systemic burden. This platform offers a promising adjunct to current colorectal cancer treatment, particularly in post-chemotherapy care. It benefits patients by reducing recurrence risk, minimising damage to healthy tissue, and improving localised tumour control. Future work will focus on in vivo validation and clinical translation.
| Item Type: | Book Chapter |
|---|---|
| Uncontrolled Keywords: | Ulam raja, Cosmos caudatus, Hydrogel, Cancer |
| Subjects: | Q Science > QD Chemistry T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering T Technology > TP Chemical technology > TP1080 Polymers, plastics and their manufacture |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Engineering > Department of Manufacturing and Materials Engineering |
| Depositing User: | Dr Syazwani Mohd Zaki |
| Date Deposited: | 27 Aug 2026 12:36 |
| Last Update: | 27 Aug 2026 12:36 |
| Queue Number: | 2026-08-Q4932 |
| URI: | http://irep.iium.edu.my/id/eprint/131015 |
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