Ajiboye, Basiru Olaitan and Onikani, Sunday Amos and Ekundayo, Bidemi Emmanuel and Oladele, Itunu Temitope and Lawal, Olaolu Ebenezer and Bello, Taoheed Olawale and Ogedengbe, Oluwatosin Olalekan and Adedeji, Odunayo Selimot and Bakhtiar, M. Taher and Khotib, Junaidi and Darnis, Deny Susanti and Okesola, Marry Abiola and Babatunji Emmanuel, Oyinloye and Vitalini, Sara and Iriti, Marcello (2026) Rebalancing hepatic carbohydrate metabolism: effects of Dalbergiella welwitschii (Baker) Baker f. (Fabaceae) under diabetic conditions. AIMS Molecular Science, 13 (2). pp. 168-179. ISSN 2372-0301
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Abstract
This study evaluated the effects of an alkaloid-rich leaf extract of Dalbergiella welwitschii (Baker) Baker f. on hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats. Diabetes was induced in rats, which were then treated with low (50 mg/kg) and high (100 mg/kg) doses of the extract, or metformin (200 mg/kg), for 20 days. Key hepatic enzymes—glycogen phosphorylase, glucose-6-phosphatase, lactate dehydrogenase, fructose-1,6-bisphosphatase, glycogen synthase, and hexokinase—along with hepatic glycogen and insulin levels were measured. Treatment with the extract significantly restored enzyme activities, increased insulin levels, and enhanced glycogen content. These results indicate that D. welwitschii extract can modulate hepatic carbohydrate metabolism and may have potential therapeutic benefits for diabetes management.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | alkaloids; diabetes mellitus; hepatic enzymes; phytotherapy; west African blackwood |
| Subjects: | Q Science > Q Science (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Chemistry |
| Depositing User: | Dr Deny Susanti Darnis |
| Date Deposited: | 02 Aug 2026 22:47 |
| Last Update: | 02 Aug 2026 22:47 |
| Queue Number: | 2026-07-Q4446 |
| URI: | http://irep.iium.edu.my/id/eprint/130412 |
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