Emerging the potential of mRNA technology in Covid-19 vaccine manufacturing

Bakhtiar, M. Taher and Mohd Rosdi, Muhammad Imtiaaz Aziman and Mohd Nizam Nur, Muhammad Syahmil Irsyad and Zainuri, Qurratu Ain and Mohd Nor Shokri, Nur Shafira Izzatie and Mohd Pazli, Nureen Hannani and Darnis, Deny Susanti and Zaini, Erizal and Khotib, Junaidi (2026) Emerging the potential of mRNA technology in Covid-19 vaccine manufacturing. In: Springer Handbook of Medical Biotechnology. Springer, Switzerland, pp. 315-332. ISBN 978-3-032-01635-5

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Abstract

The COVID-19 pandemic, originating from SARS-CoV-2 has threatened global health severely. The efforts to combat it involve extensive vaccine development using diverse methods including whole virus, protein-based, and nucleic acid (DNA and RNA) technologies. The mRNA vaccine, a notable advancement, gained emergency approval, signifying a significant milestone in nucleic acid vaccination. These vaccines aim to provide effective immunization against the virus, crucial in facing the pandemic’s unprecedented global threat. This chapter reports a comprehensive literature review discussing how new technology of mRNA vaccine can be utilized in the manufacturing process of COVID-19 vaccines. The mRNA COVID-19 vaccines such as Pfizer-BioNTech’s BNT162b2 and Moderna’s mRNA-1273 have revolutionized the global pandemic response. They employ mRNA to instruct cells to generate immune responses. The mechanism involves mRNA encoding specific antigens, inducing robust immune responses against targeted diseases such as COVID-19. In terms of formulation, mRNA utilizes lipid nanoparticles to enter the cells, initiating protein synthesis and immune responses, crucial for preventing disease onset. COVID-19 mRNA vaccine development, distribution strategies, production processes, and comparisons with other vaccine’s technology were discussed comprehensively. Prioritization of vaccine distribution is generally given to health and social care workers, residents and staff of residential nursing homes for the elderly, and elderly people.

Item Type:	Book Chapter
Uncontrolled Keywords:	Virus · COVID-19 · mRNA vaccine · Immune response · Nucleic acid
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	18 May 2026 12:47
Last Modified:	18 May 2026 12:47
Queue Number:	2026-05-Q3348
URI:	http://irep.iium.edu.my/id/eprint/128986

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