A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer

Khai Voon, Kelvin Wong and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and UNSPECIFIED (2022) A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer. Journal of Computational Biophysics and Chemistry, 21 (6). pp. 611-627. ISSN 2737-4165 E-ISSN 2737-4173

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Abstract

Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on �; �-unsaturated carbonyl molecules. Structural modifications to �; �-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic �; �-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies.

Item Type:	Article (Journal)
Uncontrolled Keywords:	�; -unsaturated carbonyl; breast cancer; mTOR pathway; molecular docking; SAR.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy
Depositing User:	Dr Kamal Rullah
Date Deposited:	23 Nov 2022 09:33
Last Modified:	23 Nov 2022 09:39
URI:	http://irep.iium.edu.my/id/eprint/101414

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