Microbial biotransformation of anthraquinone and biological activity: a review

Ahmed, Qamar Uddin and Amran, Nursyafiqqah Najwa (2022) Microbial biotransformation of anthraquinone and biological activity: a review. Journal of Pharmacy, 2 (2). pp. 69-88. ISSN 27735664

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Abstract

Anthraquinones are known to have multiple biological activities such as antioxidant, cytotoxicity, antibacterial, antifungal, and antimalarial activities. Despite that, microbial biotransformation of anthraquinones has been extensively carried out to modify or synthesise new anthraquinone derivatives which were technically hard to be chemically synthesised. It is an easy way to discover and synthesise new medicinal compounds having potent pharmacological properties. The synthesis of desired compounds requires less time and less energy. It also promises low cost of production and less environmental impact. Some of the reactions involved were dehalogenation, hydrolysis, oxidation, and glycosylation. The new compounds might possess new biological activities or might exert a better pharmacokinetic profile than the parent compound. However, until recently, there was no in-vivo study had been done to evaluate the pharmacodynamics profile of microbial biotransformed anthraquinones. If the in-vitro study is successful, we can expect a high probability of a positive result in an in-vivo study. Nonetheless, microbial biotransformation is an alternative way to discover new future drugs alongside the synthetic pathway. This review summarises articles related to microbial biotransformation of anthraquinones for the past 20 years.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Anthraquinone, biotransformation, microbes, new bioactive compounds
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	10 Aug 2022 08:27
Last Modified:	10 Aug 2022 08:38
URI:	http://irep.iium.edu.my/id/eprint/99321

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