Hilles, Ayah Rebhi and Syed, Mahmood and I. Waly, Mostafa and Kaderi, Mohd Arifin and Ahmed, Qamar Uddin and Hejaz Azmi, Syed Najmul and F. AlAsmari, Abdullah and Ali, Nemat and Alharbi, Metab and Rauf, Mohd Ahmar (2022) The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus): In vivo evaluation and histological evidence. Journal of King Saud University – Science, 34 (4). p. 102011. ISSN 1018-3647
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Abstract
Objectives The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods The eel mucus was collected fleshly and topical gel with carbopol 934 was formulated to study the antibacterial activity on the infected skin of the rats. Sprague Dawley rats were used in the study and divided into 4 groups negative, positive, normal control, and treated groups. Results Intracutaneous injections of pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus) and fungi (Microsporum gypseum, Candida albicans) were injected into the rats. The development of tinea capitis, impetigo, and cutaneous candidiasis in the animal model was confirmed based on clinical and histopathological observations. To treat the infected rats, a formulated gel of eel skin mucus was applied on the infected rat’s skins topically. The histological analysis confirms a complete recovery in the skin tissues similar to commercial antifungal and antibacterial agents used in the positive control groups. Conclusion The present novel eel skin mucus is an efficient therapeutic candidate in treating skin infections associated with pathogenic microbes.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | Eel skin mucus, Monopterus albus, Intracutaneous injections, Skin infections |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Allied Health Sciences Kulliyyah of Pharmacy |
| Depositing User: | Dr Qamar Uddin Ahmed |
| Date Deposited: | 19 May 2022 09:26 |
| Last Modified: | 03 Jun 2022 10:31 |
| URI: | http://irep.iium.edu.my/id/eprint/97920 |
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