Neuroprotective and anxiolytic effects of date seeds phenolic compounds in nicotinamide-streptozotocin-induced Type 2 diabetic rats

Samir, Bikri and Youssef, Aboussaleh and Mohamed, Wael Mohamed Yousef (2022) Neuroprotective and anxiolytic effects of date seeds phenolic compounds in nicotinamide-streptozotocin-induced Type 2 diabetic rats. In: Role of Nutrients in Neurological Disorders. Nutritional Neurosciences . Springer, pp. 125-142. ISBN 978-981-16-8157-8

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Abstract

Several experimental and clinical data revealed that type 2 diabetes (T2D) is linked with behavioral and biochemical alterations. Date grains, one of the important valuable natural by-products with antioxidant and anti-inflammatory proprieties, have been revealed to have many benefits against diabetes mellitus and its complications. The present work aims to investigate the protective and anxiolytic effects of date seeds extract (DSE) in T2D rat model. Animals were divided into four groups as follows: Group 1 (diabetic control), groups 2 and 3 were diabetic treated with metformin (Met, 300 mg/kg) and DSE (2000 mg/kg), respectively, and the group 4 was normal control. Each group contains 10 rats. T2D in these rats was induced by an intraperitoneal injection of Streptozotocin (65 mg/kg) and Nicotinamide (110 mg/kg) (15 min between the two injections). Treatment lasted for 42 days just after diabetes confirmation. Anxiety-related behavior of rats was evaluated just before sacrifice using four behavioral tests. After rats were sacrificed, the brain was dissected out in order to assess tumor necrosis factor-alpha and lipid peroxidation levels in prefrontal cortex as well as in Hippocampus. Treatments with metformin and/or DSE remarkably decreased the tumor necrosis factor-alpha levels and prevent the lipid peroxidation generation in prefrontal cortex and hippocampus in streptozotocin-nicotinamide diabetic rats. Moreover, the administration of metformin or DSE for 42 days prevented significantly anxiety-related behavior in these rats. In summary, the results of the present study revealed that DSE exhibited anxiolytic propriety in T2D rats, which might be due to its powerful anti-inflammatory and antioxidant proprieties.

Item Type:	Book Chapter
Uncontrolled Keywords:	Type 2 diabetes, Date seeds, Anxiety, Tumor necrosis factor-alpha, Lipid peroxidation
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	24 Mar 2022 12:37
Last Modified:	24 Mar 2022 12:37
URI:	http://irep.iium.edu.my/id/eprint/97341

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