Natural quinolone antimicrobial agents from Malaysian Rutaceous species

Mohd Hassan, Norazian and Md Taib, Nurhaya and Mohd Kamal, Laina Zarisa and Abdul Karim, Khairul Anuar and Abdul Karim, Khairul Anuar and May, Khin Soe (2011) Natural quinolone antimicrobial agents from Malaysian Rutaceous species. In: IIUM Research, Invention and Innovation Exhibition IRIIE 2011, 9-10 February 2011, Kuala Lumpur, Malaysia.

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Abstract

Various 4-oxygenated and 2-substituted 4-quinolone alkaloids with diverse structural types have been isolated and were found unique to the Rutaceae plant family. Some of these alkaloids have been demonstrated to have promising antimicrobial activity. These alkaloids possess chromophore with some structural similarities to that of the pharmacophore of the conventional 4-quinolone antimicrobial agents. Therefore it is presumed that this type of natural quinolone alkaloid could also share the same activity as the conventional agents. Three Malaysian Rutaceous species have been investigated for their natural quinolone antimicrobial agents, namely Glycosmis pentaphylla (Retz.) DC., Lunasia amara Blanco and Ruta angustifolia (L.) Pers. Bioassay-guided isolation facilitated by using bioautographic agar overlay assay against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35213 and Candida albicans ATCC 90028 as the indicator microbes has led to the isolation of antimicrobial 4-quinozolone alkaloid, identified as arborine, 2-quinolone namely lunidonine and 4-quinolone with the trivial name graveoline from G. pentaphylla, L. amara and R. angustifolia, respectively. These alkaloids possess promising antimicrobial activity with the minimum inhibitory concentrations (MICs) ranging between 125 µg/ml and 250 µg/ml against the tested microbes. Arborine and graveoline showed synergistic antimicrobial effect when tested in combination with ampicillin against E. coli with FIC index of 0.38 for each combination. These results show a great importance in view of finding a new structural type in overcoming the emergence of quinolone resistance against some microbes which has been a disturbing feature of microbial infections.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	4171/9699
Uncontrolled Keywords:	Natural Quinolone, Antimicrobial Agents, Malaysian Rutaceae
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology > QR180 Immunology R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Norazian Mohd Hassan
Date Deposited:	23 Feb 2012 12:36
Last Modified:	23 Feb 2012 12:36
URI:	http://irep.iium.edu.my/id/eprint/9699

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