Association between LRRTM1 gene DNA methylation and schizophrenia psychopathology

Abdull Jalil, Mohd Asyraf and Abd Rahim, Nour El Huda and Mohd Noor, Hanisah and Ku Zaifah, Norsidah and A. Talib, Norlelawati (2021) Association between LRRTM1 gene DNA methylation and schizophrenia psychopathology. In: Medical Research Symposium 2021, 14 December 2021, Kuantan, Pahang. (Unpublished)

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Abstract

Introduction: Leucine-rich-repeat transmembrane neuronal protein 1 (LRRTM1) is a synaptic adhesion molecule involved in synapse organization. DNA hypomethylation of the LRRTM1 gene promoter was shown to be associated with familial schizophrenia. However, the association with schizophrenia in general and its symptom severity is still unknown. This study aimed to investigate the DNA methylation level of LRRTM1 gene in schizophrenia patients and its relationship with psychopathology. Methods: In this study, 183 schizophrenia patients and 212 healthy controls were included. The DNA methylation level was measured using MethyLight quantitative PCR assay on bisulfite converted genomic DNA from peripheral blood. The methylation levels were measured as percentage of methylated reference (PMR). Psychopathology was assessed using five-factor Positive and Negative Syndrome Scale (PANSS) and Personal and Social Performance Scale (PSP). Results: There was no significant difference in the DNA methylation level of LRRTM1 between the patients and healthy control group. However, there were significant negative correlation between LRRTM1 DNA methylation level and total PANSS (rho = -0.156), negative symptoms (rho = -0.147) and disorganization symptoms (rho = -0.171) scores respectively (all p <0.05). In addition, there was significant positive correlation between LRRTM1 DNA methylation level with PSP scores (rho = 0.19, p = 0.01) Conclusion: The observed inverse relationship between LRRTM1 DNA methylation and schizophrenia symptom severity supports potential role of LRRTM1 dysregulation in the psychopathology of schizophrenia, in line with theory of synapse integrity.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7013/95799
Uncontrolled Keywords:	DNA methylation, LRRTM1, psychopathology, schizophrenia
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr Mohd Asyraf Abdull Jalil
Date Deposited:	31 Dec 2021 13:10
Last Modified:	21 Jul 2022 09:39
URI:	http://irep.iium.edu.my/id/eprint/95799

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