Soft‑chewable paracetamol tablets by Melt Granulation Method: formulation and characterization

Mohmad Sabere, Awis Sukarni and Mohd Suhaimi, Nur Anis Najlaa and Ahmed, Qamar Uddin and Mahat, Mohd Muzamir and Che Roslan, Nazreen and Azizi, Juzaili (2021) Soft‑chewable paracetamol tablets by Melt Granulation Method: formulation and characterization. Journal of Pharmacy and Bioallied Sciences, 13 (3). pp. 312-316. ISSN 0976-4879 E-ISSN 0975-7406

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Abstract

Oral drug delivery is the most preferred route for drug administration in the world, with tablets being one of the most common dosage forms. However, some people, particularly children and the elderly, have difficulty swallowing the tablets. Chewable tablets are the dosage form that can address the issue while also providing a valuable masking effect on drug taste, allowing patients to swallow the drugs more easily. Materials and Methods: In this study, the chewable tablets were manufactured using the melt granulation method, which resulted in tablets with a chewy texture. The tablets contained paracetamol as well as Arabic gum, starch, agar, and mannitol. Results: The drug release profiles for the fragmented form showed that 50% of the drug was released within 4 min and 100% was released within 30 min of the dissolution process. The intact form released nearly 90% of the drug within 2 h. Conclusion: Formulation 2 was determined as the best formulation. This tablets' formulation had passed all characterization tests and displayed a moderate hardness and chewy texture.

Item Type:	Article (Journal)
Additional Information:	94588/7758
Uncontrolled Keywords:	Chewable tablets, melt granulation, paracetamol
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Awis Sukarni Mohmad Sabere
Date Deposited:	09 Dec 2021 11:45
Last Modified:	24 Mar 2022 14:05
URI:	http://irep.iium.edu.my/id/eprint/94588

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