In vitro evaluation of crosslinked polyvinyl alcohol/chitosan – gentamicin sulfate electrospun nanofibers

Hamdan, Nazirah and Susanti, Deny and Khodir, Wan Khartini Wan Abdul (2021) In vitro evaluation of crosslinked polyvinyl alcohol/chitosan – gentamicin sulfate electrospun nanofibers. Malaysian Journal of Chemistry, 23 (2). pp. 1-10. E-ISSN 2550-1658

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Abstract

Polymeric nanofibers with good antimicrobial properties are a promising option to thwart wound infection and accelerate wound healing. Although PVA/Chitosan possesses many useful properties, its antibacterial activity is insufficient for effective wound dressing. Therefore, using a hydrophilic drug such as Gentamicin Sulfate (GS) that has a broad-spectrum activity against a wide range of bacteria can enhance the nanofibers’ performance. In this study, polyvinyl alcohol (PVA) with chitosan nanofibers loaded with gentamicin sulfate was prepared using an electrospinning technique and crosslinked with glutaraldehyde for better loading efficiency and controlled drug release at the site of interest. Morphological investigation carried out using scanning electron microscopy showed smooth and homogeneous nanofibers. FT-IR was used to confirm the structure of the nanofibers. In situ crosslinking enabled penetration of the crosslinking agent into the nanofibers and improved the thermal stability and drug release performance. The thermal stability of PVA/Chitosan nanofibers was reduced with the addition of gentamicin sulfate. The kinetic release of gentamicin sulfate followed the Korsmeyer-Peppas model with release exponent, n < 0.5. Antibacterial testing of crosslinked nanofibers against Escherichia coli and Staphylococcus aureus showed good inhibition of bacterial growth. Crosslinked PVA/Chitosan nanofibers loaded with gentamicin sulfate showed multifunctional characteristics and thus may be a suitable material for controlled drug delivery and tissue engineering applications.

Item Type:	Article (Journal)
Additional Information:	6822/93383
Uncontrolled Keywords:	Polyvinyl alcohol; chitosan; nanofibers; controlled release
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry Kulliyyah of Science
Depositing User:	WAN KHARTINI WAN ABDUL KHODIR
Date Deposited:	29 Oct 2021 14:47
Last Modified:	29 Oct 2021 14:47
URI:	http://irep.iium.edu.my/id/eprint/93383

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