Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine

Ibrahim, Maizatul Akma and Husin, Atiyah and Ngah, Nurziana and Zakaria, Nor Hafizah (2021) Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine. Journal Clean WAS (JCleanWAS), 5 (1). pp. 35-38. ISSN 2521-0912 E-ISSN 2521-0513

PDF (Article) - Published Version Restricted to Registered users only Download (723kB) | Request a copy

Abstract

Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacterial activity of the compounds was conducted by using the disc diffusion method and minimal inhibitory concentration (MIC) as well as minimal bactericidal concentration (MBC). The results indicate that 4-fluorobenzoylthiourea α-alanine, benzoylthiourea α-alanine, 4-fluorobenzoylthiourea β-alanine, 4-chlorobenzoylthiourea β-alanine, 4-bromobenzoylthiourea β-alanine, and benzoylthiourea β-alanine possess weak to strong antibacterial activity on all of tested bacteria. The strongest antibacterial activity was found in the 4-fluorobenzoylthiourea α-alanine, whereas the weakest antibacterial activity was exhibited in 4-fluorobenzoylthiourea β-alanine. S. aureus was found the most susceptible toward these thiourea derivatives, indicating bactericidal activity against the bacteria.

Item Type:	Article (Journal)
Additional Information:	7138/93002
Uncontrolled Keywords:	benzoyl thiourea, halobenzoyl thiourea, antibacterial, disc diffusion test, minimum inhibition concentration
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology Kulliyyah of Science > Department of Chemistry Kulliyyah of Science > Department of Plant Science
Depositing User:	Dr Maizatul Ibrahim
Date Deposited:	13 Oct 2021 11:28
Last Modified:	13 Oct 2021 11:28
URI:	http://irep.iium.edu.my/id/eprint/93002

Actions (login required)

View Item