The positive impact of vitamin C (Ascorbic Acid) utilisation in cancer treatment: a scoping review of published articles from the perspective of the in vitro studies

Mohammad Hamdi, Nurul Ain and Haris @ Harith, Muhammad Salahuddin and Harun Ismail, Ahmad Fahmi (2021) The positive impact of vitamin C (Ascorbic Acid) utilisation in cancer treatment: a scoping review of published articles from the perspective of the in vitro studies. Malaysian Journal of Medicine and Health Sciences, 17 (4). pp. 275-284. ISSN 1675-8544 E-ISSN 2636-9346

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Abstract

Survival benefit of patients with advanced cancer was reported with intravenous vitamin C administration. Nev�ertheless, a recent systematic review failed to support the clinically use of vitamin C in cancer patients due to the diversity of interventions and cancer type. This study aimed to provide a scoping review of vitamin C utilisation and its impact on cancer treatment from the perspective of in vitro studies. The review was conducted using predefined search terms in three scientific databases. 44 articles were retrieved with a total of 15 cancer types being studied from 2015 to 2020. The findings were classified into primary and secondary outcome. The primary outcome refers to chief consequences of vitamin C treatment, while the secondary outcome denotes the additional advantages generated as a result of the primary outcome, which occurs both in monotherapy and combination therapy. This review discussed the major mechanism of vitamin C as anti-cancer and its relation with the outcomes.

Item Type:	Article (Review)
Additional Information:	6657/92939
Uncontrolled Keywords:	Ascorbic acid, Vitamin C, Treat cancer, Anti-cancer, in vitro study
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Physical Rehabilitation Sciences Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Muhammad Salahuddin Haris
Date Deposited:	11 Oct 2021 12:32
Last Modified:	11 Oct 2021 12:32
URI:	http://irep.iium.edu.my/id/eprint/92939

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