Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review

Mia, Abdur Rashid and Ferdosh, Sahena and Ahmed, Qamar Uddin and Helal Uddin, A.B.M. and Sarker, Md. Zaidul Islam (2021) Bridging indigenous knowledge and scientific evidence for pharmacological studies of phaleria macrocarpa: a review. The Natural Products Journal. pp. 1-17. ISSN 2210-3155 E-ISSN 2210-3163

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Abstract

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne, and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities, thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Methods: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids, etc., were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates anti-diabetic, anti- oxidant, antimicrobial, anticancer, anti-hypercholesterolemia, and antihypertensive activities. Conclusion: Despite various claims, there is still inadequate scientific evidence, particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases, and rheumatoid arthritis, necessitating future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties.

Item Type:	Article (Journal)
Additional Information:	7165/92577
Uncontrolled Keywords:	Phaleria macrocarpa, traditional evidence, phytochemistry, anticancer, anti-diabetic, toxicity
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Science > Department of Plant Science Kulliyyah of Pharmacy Kulliyyah of Science
Depositing User:	Dr. Sahena Ferdosh
Date Deposited:	05 Oct 2021 16:35
Last Modified:	07 Jul 2022 15:15
URI:	http://irep.iium.edu.my/id/eprint/92577

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