New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm

Jani, Nor Akmalazura and Sirat, Hasnah Mohd and Ahmad, Farediah and Aminudin, Nurul Iman (2021) New sesquiterpene dilactone and β-carboline alkaloid and the α-glucosidase inhibitory activity of selected phytochemicals from Neolitsea cassia (L.) Kosterm. Natural Product Research. pp. 1-9. ISSN 1478-6419 E-ISSN 1478-6427

PDF Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

One new sesquiterpene dilactone, coccinine (1) and one new b-carboline alkaloid, daibucarboline F (2) together with 10 known compounds; linderane (3), linderalactone (4), pseudoneolinderane (5), linderanlide C (6), linderanine A (7), epicatechin (8), (�)-taxifolin (9), astilbin (10), L-quercitrin (11) and afzelin (12) were isolated from the stems and leaves of Neolitsea cassia (L.) Kosterm (Lauraceae). The structures of (1 and 2) were established by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in literature. The relative stereochemistry of compound (1) was assigned by Xray diffraction analysis with Cu-Ka irradiation. Compounds (3-8) and (10) were evaluated for their a-glucosidase enzymatic inhibitory activity. Compounds (4-6), (8) and (10) exhibited inhibition towards a-glucosidase enzymatic activity with IC50 values ranging from 12.10 to 96.77 lM. This is the first report on the isolation of phytochemicals from N. cassia and their bioactivities.

Item Type:	Article (Journal)
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Nurul Iman Aminudin
Date Deposited:	21 Sep 2021 11:33
Last Modified:	21 Sep 2021 11:33
URI:	http://irep.iium.edu.my/id/eprint/92382

Actions (login required)

View Item