The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)

Mat Nor, Mohd Basri and Samiullah, Saeed and Md Ralib, Azrina and Mohamad Aidid, Edre (2021) The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study). In: Kuantan Research Day 2020: A National Online Event for E-poster Presentation, Kuantan, Pahang.

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Abstract

Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients. This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients. Methods: Sixty mechanically ventilated patients expected to stay in intensive care unit (ICU) more than 3 days were randomized into a group in which energy needs were determined by IC (IC-group) and a group prescribed with 25kcal/kg/day reflecting standard care (SC-group). The primary outcome was the ICU length of stay(LOS). Secondary outcomes included change in quadriceps muscle layer thickness (QMLT, ultrasound) during the first 10 days of ICU admission, hospital-LOS, duration of mechanical ventilation, ICU mortality and 28-day-in hospital mortality. Results: Mean energy requirement was similar in both groups. The IC group received 85.63%, whereas the SC group received 76.83% of their energy goals (P=0.002). The protein intake was higher in the IC group (89.58% vs 77.66%, p=0.007). Both groups had a median of 8.0 days ICU-LOS (p=0.424). QMLT was decreased in both groups by 21.9% vs. 25.3% at day10 (p < 0.001), respectively. However, there were no significant differences observed in muscle mass changes and other secondary clinical outcomes between the groups. Conclusion: IC-guided nutrition did not appear to affect significantly any clinical outcomes compared to the SC group due to the limitation in Sample size. Clinicaltrials.gov identifier no. NCT04479254

Item Type:	Conference or Workshop Item (Poster)
Uncontrolled Keywords:	Indirect calorimetry, feeding protocol, Critically ill, Randomized Controlled trial
Subjects:	R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Dr. Mohd Basri Mat Nor
Date Deposited:	20 Aug 2021 18:16
Last Modified:	20 Aug 2021 18:16
URI:	http://irep.iium.edu.my/id/eprint/91493

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