Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells

Doolaanea, Abd Almonem and Hassani, A and Hussain, SA and Enezei, HH and Saeed, S and Ibrahim, WN and Al-Qubaisi, MS and Zentou, H and Rosli, R (2020) Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells. IOP Conf. Series: Materials Science and Engineering 991 (2020), 991. p. 166005.

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Abstract

Curcumin nanoparticles)Cur/GANPs(were formulated based on gum arabic)GA(as a stabilizer coatings for nanoparticles through efficient synthesis approach . The current study investigated the antioxidant properties and antihypertensive activity of curcumin)Cur(using various established in vitro assays, such as 1,1-diphenyl-2-picrylhydrazyl)DPPH(as well as angiotensin converting enzyme (ACE(inhibitory activity. The in vitro cytotoxicity of Cur/GANPs against human liver cancer)HepG2(, and colon cancer)HT29(was investigated. The exposure of human cancer cells to Cur/GANPs)1.56-100 µg/ml(using MTT)3-)4,5-dimethylthiazol-2-yl(2,5-diphenyl tetrazolium bromide(has revealed that the Cur/GANPs inhibited the growth of cell lines examined in a dose dependent manner. Hence, Cur/GANPs nanoparticles may have great potential to be applied for cancer treatment.

Item Type:	Article (Journal)
Additional Information:	88847/7245
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Abd Almonem Doolaanea
Date Deposited:	12 Mar 2021 09:45
Last Modified:	15 Mar 2021 06:21
URI:	http://irep.iium.edu.my/id/eprint/88847

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