Horseshoe crab genomes reveal evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication in invertebrates

Nong, Wenyan and Qu, Zhe and Li, Yiqian and Owen, Tom Barton and . Wong, Annette Y. P and John, Akbar and UNSPECIFIED (2021) Horseshoe crab genomes reveal evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication in invertebrates. Communication Biology, 4 (1). pp. 1-11. ISSN 2399-3642

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Abstract

Whole genome duplication (WGD) has occurred in relatively few sexually reproducing invertebrates. Consequently, the WGD that occurred in the common ancestor of horseshoe crabs ~135 million years ago provides a rare opportunity to decipher the evolutionary consequences of a duplicated invertebrate genome. Here, we present a high-quality genome assembly for the mangrove horseshoe crab Carcinoscorpius rotundicauda (1.7 Gb, N50 = 90.2 Mb, with 89.8% sequences anchored to 16 pseudomolecules, 2n = 32), and a resequenced genome of the tri-spine horseshoe crab Tachypleus tridentatus (1.7 Gb, N50 = 109.7 Mb). Analyses of gene families, microRNAs, and synteny show that horseshoe crabs have undergone three rounds (3R) of WGD. Comparison of C. rotundicauda and T. tridentatus genomes from populations from several geographic locations further elucidates the diverse fates of both coding and noncoding genes. Together, the present study represents a cornerstone for improving our understanding of invertebrate WGD events on the evolutionary fates of genes and microRNAs, at both the individual and population level. We also provide improved genomic resources for horseshoe crabs, of applied value for breeding programs and conservation of this fascinating and unusual invertebrate lineage

Item Type:	Article (Journal)
Additional Information:	7130/87972
Uncontrolled Keywords:	Horseshoe crab genomes, genes, microRNAs three rounds (3R), whole genome duplication, in invertebrates
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Institute of Oceanography and Maritime Studies
Depositing User:	Dr. Akbar John
Date Deposited:	25 Jan 2021 10:22
Last Modified:	23 Jun 2021 16:32
URI:	http://irep.iium.edu.my/id/eprint/87972

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