Potential nanospray inhalation of remdesivir and hydroxychloroquine using poly (lactic-co-glycolic) acid as fast delivery for covid-19 treatment

Bakhtiar, M. Taher and Shaari, Siti Syazwani and Darnis, Deny Susanti (2021) Potential nanospray inhalation of remdesivir and hydroxychloroquine using poly (lactic-co-glycolic) acid as fast delivery for covid-19 treatment. Journal of Pharmacy, 1. pp. 34-44. E-ISSN 2773-5664

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Abstract

Introduction: The oral medication of remdesivir and hydroxychloroquineface several limitations in covid-19 therapy. Despite having the first-pass metabolism, it also has a limitation in the patient who has hospitalised with a severe covid-19 infection. It is especially for a drug that is targeting the angiotensin-converting enzyme II (ACE2) receptor where the receptors are found abundantly in the lung, kidney, heart, and gastrointestinal tract. Therefore, an alternative delivery such as nanospray inhalation would provide a great benefit to those patients. Methods: Scientific sources from Scopus, PubMed, Google Scholar, EBSCO, ScienceDirect, and Elsevier were accessed for publication of this review article regarding the nanospray inhalation for Covid-19. Results: Since the main organ infected by SARS-CoV-2 is the tracheaand lung, inhalation may be the best route to deliver the drug tothe site of action. It is proposed that poly (lactic-co-glycolic)acid to be used in the formulation.Conclusion:Poly (lactic-co-glycolic)acid (PLGA) is considered a suitable polymer since it is biocompatible and noncytotoxic, it is the most widely applied in drug delivery either as carrier or excipient for the optimal formulation and distribution of the drugs. Dry powder inhalation of remdesivir and hydroxychloroquine may be an alternative way to deliver the drug against Covid-19

Item Type:	Article (Journal)
Additional Information:	5209/87947
Uncontrolled Keywords:	COVID-19, nanospray,hydroxychloroquine, remdesivir, inhalation, antivira
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Muhammad Taher
Date Deposited:	21 Jan 2021 21:30
Last Modified:	21 Jan 2021 21:30
URI:	http://irep.iium.edu.my/id/eprint/87947

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