Tualang honey and DHA-rich fish oil reduce the production of pro-inflammatory cytokines in the rat brain following exposure to chronic stress

Asari, Mohd Asnizam and Zulkaflee, Mohd Hazim and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Mohd Yusof, Nurul A and Mohd Sairazi, Nur Shafika (2019) Tualang honey and DHA-rich fish oil reduce the production of pro-inflammatory cytokines in the rat brain following exposure to chronic stress. Journal of Taibah University Medical Sciences, 14 (4). pp. 317-323. ISSN 16583612

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Abstract

Objectives: The aim of the present study was to investigate the effects of Tualang honey (TH), DHA-rich fish oil, and their combination on the concentrations of selected pro-inflammatory cytokines in rat brains following exposure to chronic stress. Methods: Fifty male SpragueeDawley rats were divided into (i) control, (ii) stress-exposed, (iii) stress-exposed and treated with TH (1 g/kg body weight twice daily via oral gavage), (iv) stress-exposed and treated with DHA-rich fish oil (450 mg/kg body weight twice daily via oral gavage), and (v) stress-exposed and treated with a combination of TH and DHA-rich fish oil. The chronic stress regimen consisted of a combination of restraint stress and a swim stress test for 28 days. The concentrations of selected pro-inflammatory cytokines in brain homogenates (TNF-a, IL6, and IFN-g) were measured by ELISA. Results: The concentrations of TNF-a, IL6, and IFN-g in brain homogenates from the DHA, TH, and TH þ DHA-treated groups were significantly lower compared to the control and stress-only-exposed groups (p < 0.05), but no difference was observed between treatment groups. Conclusion: Consumption of DHA-rich fish oil and TH can be effective in lowering pro-inflammatory cytokine levels in the brains of rats under chronic stress conditions. However, consuming these agents together does not provide additional benefits compared to taking them separately.

Item Type:	Article (Journal)
Additional Information:	9547/87619
Uncontrolled Keywords:	Cytokines; DHA; Fish oil; Stress; Tualang honey
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	08 Jan 2021 16:32
Last Modified:	08 Jan 2021 16:32
URI:	http://irep.iium.edu.my/id/eprint/87619

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