Siddiqi, Mohammad Umar and Saleh, Mohammed S M and Mat So'ad, Siti Zaiton
(2020)
Effect of different drying treatments and different extraction methods on alpha-Glucosidase inhibitory activities of S. zalacca fruit.
Journal of Pharmacy & Bipallied Sciences, 12 (Supplement 2).
p. 912.
ISSN 0976-4879
E-ISSN 0975-7406
Abstract
Introduction: Salacca zalacca (Gaertn Voss), commonly
known as snake fruit and belongs to the Arecaceae family
and natives of Southeast Asia. This fruit is edible and have
certain medicinal values. Objectives: The aim of this study
was to compare the α-glucosidase inhibitory activities of
different drying and extraction methods. Material and
methods: Flesh of this fruit was subjected to two different
drying methods namely; oven dried (OD) and freeze
dried (FD) and extracts were prepared using soxhlet (SX),
sonication (SC) and maceration (MC) techniques. The
α-glucosidase inhibitory activity of extracts were evaluated
using α-glucosidase enzyme. Results: The S. zalacca
fruit extracts obtained through SC and MC demonstrated
better α-glucosidase inhibitory activity as compared
to SX method, specifically, the FD extracts showed
higher activity compared to the OD extracts. Analysis of
α-glucosidase inhibitory activity of the OD S. zalacca fruit
extract indicates that extract obtained through SC method
possesses significantly higher activity (IC50 79.42 μg/mL)
than that of SX extracted sample which displayed IC50 at 125.73 μg/mL. Considering the effects of both methods
(drying and extraction) on the α-glucosidase inhibitory
activity of S. zalacca fruit extracts, extract obtained through
SC of the FD fruits demonstrated the highest activity
(IC50 19.40 μg/mL) Meanwhile, extracts obtained via OD
and different extraction methods such as SX, MC and SC
showed the least inhibition with IC50 125.73, 87.23 and
79.42 μg/mL, respectively. Conclusion: This study suggests
that S. zalacca fruit has the potential for nutraceutical
enhancement and as ingredient in medicinal preparation.
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