Aslam, Adeel and Nokhala, Ahmed and Peerzada, Sohaib and Ahmed, Shoaib and Khan, Tanveer and Siddiqui, Mohammad Jamshed Ahmad (2020) Evaluation and comparison of Trachyspermum ammi seed extract for its anti-inflammatory effect. Journal of Pharmacy & Bioallied Sciences, 12 (6). pp. 777-780. ISSN 0976-4879 E-ISSN 0975-7406
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Abstract
Aims and Objectives: The present study was aimed to evaluate the anti-inflammatory effect of different seed extracts of Trachyspermum ammi at different doses. Materials and Methods: Three different seed extracts were prepared through Soxhlet extraction method by using n-hexane, chloroform and methanol solvents. Acute toxicity test performed at dose of 400 mg/kg, 800 mg/kg, 1600 mg/kg and 3200 mg/kg. Two different strengths of seed extracts (minimum therapeutic dose of 500 mg/kg and maximum therapeutic dose of 1000 mg/kg) were given to Wistar rats to measure anti-inflammatory activity through Carrageenan induced paw edema method. Results: The standard drug diclofenac sodium was (percentage of inhibition of paw edema 29.68%) more effective as compared to test drug. When efficacy of all extracts compared with each other, n-hexane extract showed more anti-inflammatory effect (percentage inhibition of paw edema 22.21%) at maximum effective dose 1000 mg/kg. Conclusion: Seed extracts of T. ammi showed anti-inflammatory activity by potentiating the neurotransmission of GABA and also by repression glutamate receptor.
Item Type: | Article (Journal) |
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Additional Information: | 6804/85392 |
Uncontrolled Keywords: | Acute toxicity, anti-inflammatory, Trachyspermum ammi |
Subjects: | Q Science > QD Chemistry |
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy > Department of Pharmacy Practice |
Depositing User: | Dr M Jamshed Siddiqui |
Date Deposited: | 01 Dec 2020 10:21 |
Last Modified: | 01 Dec 2020 10:21 |
URI: | http://irep.iium.edu.my/id/eprint/85392 |
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