Optimisation of alginate-pectin bead formulation using central composite design guided electrospray technique

Azhar, Muhammad Fitri and Haris @ Harith, Muhammad Salahuddin and Mohamad, Izzuddin and Noor Ismadi, Muhammad Nur Shafiq and Abu Yazid, Anis Afiful Huda and Rahman, Siti Radziah and Mohd Azlan, Nur Hakimah (2020) Optimisation of alginate-pectin bead formulation using central composite design guided electrospray technique. International Food Research Journal, 28 (4). pp. 860-870. ISSN 1985-4668 E-ISSN 2231-7546

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Abstract

Alginate-pectin beads act as a carrier in improving the oral bioavailability of bioactive compounds. Electrospray technique facilitates the production of uniform size and shape of alginate-pectin beads. Interaction between key electrospray process parameters affects the size and shape of the beads. A proper model should be employed to establish these correlating interactions. In this study, the electrospray technique was guided with a central composite design (CCD) and response surface methodology (RSM). One quadratic and one linear model were obtained for size and the sphericity coefficient, respectively. The CCD-RSM empirical model derived from this study is essential to determine significant factors and their levels in producing beads with consistent size and sphericity coefficient. The results indicate that the applied voltage has the most significant influence on size, while the alginate-pectin concentration is the most prominent factor in producing spherical beads. The quite spherical beads with a minimum size of 2.97 mm were obtained at an alginate-pectin concentration of 3.5%, a flow rate of 10.0mL/h, an applied voltage of 2.4 kV, and a distance between the nozzle and the gelation bath of 16.0 cm.

Item Type:	Article (Journal)
Additional Information:	The journal is indexed in WOS/Scopus/MyCite The first author is a Master Student
Uncontrolled Keywords:	alginate, pectin, electrospray, central composite design, sphericity
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Muhammad Salahuddin Haris
Date Deposited:	26 Nov 2020 14:40
Last Modified:	07 Sep 2021 10:58
URI:	http://irep.iium.edu.my/id/eprint/85249

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