Metabolic derangement in young adults : where does cortisol stand?

Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Abdullah, Aszrin and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah (2020) Metabolic derangement in young adults : where does cortisol stand? In: 17th Asia-Oceania Congress of Endocrinology and The 8th Seoul International Congress of Endocrinology and Metabolism, 28th-31st October 2020, Virtual Congress. (Unpublished)

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Abstract

Objectives: Cortisol, a stress hormone released from the adrenal gland, has well-recognised role in Cushings syndrome. It was suggested that cortisol could also be implicated in metabolic syndrome, which shares some features with Cushings syndrome. The aim of this study is to examine the association between cortisol and metabolic syndrome (MetS) components in a young adult population. Methods: The data from an observational cross-sectional study conducted in 2017-2018 was analysed. The study involved 240 healthy, non-diabetic subjects aged 18 to 45 years in Kuantan, Pahang, Malaysia who were recruited via purposive sampling based on blood pressure status. Fasting blood was collected for early morning serum cortisol, lipid profile and fasting blood glucose. Body mass index and haemodynamic parameters were documented. MetS was defined by the Joint Interim Statement guideline. Results: 24.2% had MetS. Serum cortisol were higher in subjects with MetS compared to those without (p = 0.035). Among the MetS components, significant association was observed between cortisol and raised blood pressure (p = 0.004), and hypertriglyceridaemia (p = 0.046). Conclusions: Cortisol was higher in young adults with MetS, specifically was associated with elevated blood pressure and hypertriglyceridaemia. Our findings suggested that cortisol could be an underlying factor of metabolic derangement in young adults, thus, a potential target for intervention.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	7963/84963
Uncontrolled Keywords:	Syndrome X, metabolic syndrome, premetabolic condition, hypercortisolism,
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases R Medicine > RC Internal medicine > RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	23 Nov 2020 15:07
Last Modified:	23 Nov 2020 15:07
URI:	http://irep.iium.edu.my/id/eprint/84963

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