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The effect of bioactive polyphenols from Anacardium occidentaleLinn. leaveson α-Amylase and dipeptidyl peptidase IV activities

Abdullah Thaidi, Nur Imanina and Mat Jusoh, Hanapi and Ghazali, Ahmad Badruddin and Susanti, Deny and Haron, Normah (2020) The effect of bioactive polyphenols from Anacardium occidentaleLinn. leaveson α-Amylase and dipeptidyl peptidase IV activities. Indonesian Journal of Chemistry, 20 (5). pp. 1010-1017. ISSN 1411-9420 E-ISSN 2460-1578

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Abstract

Anacardium occidentaleLinn. (A. occidentaleL.) leaves possess bioactive polyphenols which are associated with antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). In this study, free, soluble ester,and insoluble-bound phenolic fractions from young and mature leaves of A. occidentaleL. were extracted. Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and dipeptidyl peptidase IV (DPPIV) activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the mature leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 μg/mL) and insoluble-bound (4.87 ± 0.32 μg/mL) phenolic fractions in the mature leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble-bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p < 0.0001). Besides, soluble ester and insoluble-bound phenolic fractions showed a stronger inhibitor of DPPIV than the free phenolic (p < 0.001), irrespective of the maturity of the leaves. In conclusion, this study showed that A. occidentaleL. extracts possessed antidiabetic properties,which may potentially be used as an alternative treatment for T2DM management.

Item Type: Article (Journal)
Additional Information: 7032/84237
Uncontrolled Keywords: Anarcadium occidentaleLinn; dipeptidyl peptidase IV; α-amylase; inhibitor
Subjects: Q Science > QD Chemistry
S Agriculture > S Agriculture (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Dentistry
Kulliyyah of Science > Department of Biotechnology
Depositing User: Dr. Normah Haron
Date Deposited: 04 Nov 2020 09:27
Last Modified: 04 Nov 2020 09:27
URI: http://irep.iium.edu.my/id/eprint/84237

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