Abdullah Thaidi, Nur Imanina and Mat Jusoh, Hanapi and Ghazali, Ahmad Badruddin and Susanti, Deny and Haron, Normah (2020) The effect of bioactive polyphenols from Anacardium occidentaleLinn. leaveson α-Amylase and dipeptidyl peptidase IV activities. Indonesian Journal of Chemistry, 20 (5). pp. 1010-1017. ISSN 1411-9420 E-ISSN 2460-1578
|
PDF
- Published Version
Download (389kB) | Preview |
Abstract
Anacardium occidentaleLinn. (A. occidentaleL.) leaves possess bioactive polyphenols which are associated with antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). In this study, free, soluble ester,and insoluble-bound phenolic fractions from young and mature leaves of A. occidentaleL. were extracted. Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and dipeptidyl peptidase IV (DPPIV) activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the mature leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 μg/mL) and insoluble-bound (4.87 ± 0.32 μg/mL) phenolic fractions in the mature leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble-bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p < 0.0001). Besides, soluble ester and insoluble-bound phenolic fractions showed a stronger inhibitor of DPPIV than the free phenolic (p < 0.001), irrespective of the maturity of the leaves. In conclusion, this study showed that A. occidentaleL. extracts possessed antidiabetic properties,which may potentially be used as an alternative treatment for T2DM management.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 7032/84237 |
| Uncontrolled Keywords: | Anarcadium occidentaleLinn; dipeptidyl peptidase IV; α-amylase; inhibitor |
| Subjects: | Q Science > QD Chemistry S Agriculture > S Agriculture (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Allied Health Sciences Kulliyyah of Dentistry Kulliyyah of Science > Department of Biotechnology |
| Depositing User: | Dr. Normah Haron |
| Date Deposited: | 04 Nov 2020 09:27 |
| Last Modified: | 04 Nov 2020 09:27 |
| URI: | http://irep.iium.edu.my/id/eprint/84237 |
Actions (login required)
 |
View Item |
Download Statistics
Download Statistics