Chronic low dose organic arsenic induced liver structural damage

Saharudin, Shahida and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Buyong, Zunariah (2019) Chronic low dose organic arsenic induced liver structural damage. In: 28th Scientific Conference of the Microscopy Society Malaysia 2019, 18th - 20th December 2019, Swiss Garden Beach Resort, Kuantan, Pahang. (Unpublished)

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Abstract

Over the decades, organic arsenic has been thought to be less toxic than inorganic arsenic. Monosodium methylarsonate (MSMA) is a potent organoarsenical herbicide that is still being used in most Asian countries, even though in some countries the used has been restricted. Other organic studies reported the effects mainly on the gastrointestinal system. However, the evidence on the severity of it to the liver is still insufficient. The study objective was to investigate the effect of organic arsenic (MSMA) exposure on hepatocytes and liver sinusoidal endothelial cells (LSEC). Rats were exposed to MSMA at 63.20 mg/kg daily for 6 months duration through oral gavage daily. Control rats received distilled water ad libitum. At the end of the duration, they were sacrificed and underwent liver perfusion for tissue preservation. Liver tissue was prepared for light microscopy, scanning and transmission electron microscopy. Histopathological and ultrastructural comparison between control and treated rats were qualitatively described. Histopathological and ultrastructurally, MSMA has caused necrotic and apoptotic changes of the liver with a reduction of organelles in hepatocytes and capillarization of LSEC. Chronic low dose organic arsenic exposure showed evidence of toxicity to hepatocytes. Interestingly, LSEC demonstrated survival accommodation.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	5179/83929
Uncontrolled Keywords:	Organic Arsenic, Liver, Endothelial Cells
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	DR ZUNARIAH BUYONG
Date Deposited:	02 Nov 2020 11:43
Last Modified:	02 Nov 2020 11:43
URI:	http://irep.iium.edu.my/id/eprint/83929

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