Mechanism of antifungal activity of virgin coconut oil on cell membrane of Candida Albicans

Mukhtar, Nor Izzah and Abllah, Zurainie and Mohamad, Mohd Azrul Naim and Shahdan, Intan Azura and Haron, Ummi Aqilah (2020) Mechanism of antifungal activity of virgin coconut oil on cell membrane of Candida Albicans. Journal of International Dental and Medical Research, 13 (3). pp. 903-908. ISSN 1309-100X

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Abstract

Oral candidiasis is typically caused by diploid yeast, Candida albicans through the colonization of the yeast. Which may cause oral tissue damage and tissue invasion. The limitation of antifungal drugs such as problem with resistance development has led researchers to investigate the potential use of natural product as new target for antifungal drug development. The aim of this study is to identify the components cytoplasmic release and the morphology of C. albicans in the presence of activated virgin coconut oil (AVCO) and the crude extract of virgin coconut oil (VCO). The fungal suspensions were treated with AVCO and VCO while nystatin and 1% Tween were used as a positive and a negative control respectively. Treatment with AVCO has caused disruption of the cell membrane of C. albicans which leads to the leakage of the cytoplasmic contents while treatment with VCO which did not show any changes on the cell membrane of C. albicans after 4 h of exposure. Our results suggest the potential use of AVCO as a novel antifungal agent to control oral candidiasis and it is likely to become an alternative for conventional drugs available in the market.

Item Type:	Article (Journal)
Additional Information:	5620/83578
Uncontrolled Keywords:	Candida albicans, Oral candidiasis, Coconut oil, Antifungal activity, Activated virgin coconut oil.
Subjects:	R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Dentistry > Department of Paediatric Dentistry and Dental Public Health Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr zurainie abllah
Date Deposited:	27 Oct 2020 11:14
Last Modified:	19 Nov 2020 16:26
URI:	http://irep.iium.edu.my/id/eprint/83578

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