High sensitivity c-reactive protein: uncovering the metabolic delinquent in young adults

Wan Omar, Wan Fatein Nabeila and Abdullah, Aszrin and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah (2020) High sensitivity c-reactive protein: uncovering the metabolic delinquent in young adults. In: Hypertension Busan 2020 in conjunction with the 52nd Scientific Meeting of The Korean Society of Hypertension, Bexco, Busan , Republic of Korea.

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Abstract

Background: Metabolic syndrome is a major risk factor for cardiovascular diseases. It is increasingly common among young adults. High- sensitivity C-reactive protein (HsCRP) has been recognised as a cardiovascular biomarker. This study evaluated the association between HsCRP and metabolic syndrome in Malaysian young adult population. Method: The study was a comparative observational cross-sectional study performed in Kuantan, Pahang, Malaysia. A total of 240 young adults age 18 to 45 years were assessed for anthropometric measurements, blood pressure, fasting blood glucose and fasting lipids. Metabolic syndrome was defined using the revised Joint Interim Statement Criteria. Subjects with HsCRP protein that exceeded 10 ng/ml were excluded from subsequent analysis. Result: The prevalence of metabolic syndrome was 26.25% and no difference was seen between genders (p = 0.175). Mean high- sensitivity C-reactive protein level was 2.79 mg/l and not significantly different between genders (p = 0.807). HsCRP was significantly higher in subjects with metabolic syndrome compared to those without metabolic syndrome (p = 0.001). Significant association between increasing number of metabolic syndrome components present with HsCRP level (p < 0.05), with stronger association observed in females (p = 0.002). Conclusion: HsCRP is positively associated with metabolic syndrome in Malaysian young adults, with stronger association in females. HsCRP could serve as an adjunct to predict MetS in young adults. Prospective study is required to confirm the causality of increasing HsCRP on metabolic syndrome components.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7963/82122
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	17 Aug 2020 10:55
Last Modified:	07 Jan 2021 14:20
URI:	http://irep.iium.edu.my/id/eprint/82122

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