Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases

Mohd Sairazi, Nur Shafika and Kuttulebbai Naina Mohamed Salam, Sirajudeen (2020) Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases. Evidence-Based Complementary and Alternative Medicine, 2020. pp. 1-30. ISSN 1741-427X

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Abstract

In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. .is review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

Item Type:	Article (Review)
Additional Information:	9547/81899
Uncontrolled Keywords:	ginseng extract, natural product, neuroprotective agent, propolis, Withania somnifera extract
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	03 Aug 2020 10:25
Last Modified:	11 Jan 2021 12:50
URI:	http://irep.iium.edu.my/id/eprint/81899

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