Angiotensin II type 1 receptor (AGTR1) methylation is inversely associated with HbA1c level in non-diabetic young adults

Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Mohd. Shah, Aida Nur Sharini and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2019) Angiotensin II type 1 receptor (AGTR1) methylation is inversely associated with HbA1c level in non-diabetic young adults. In: 3rd Cambridge Oxford Sunway Biomedical Symposium. Diabetes: Disarming The Silent Killer, 26th till 27 March 2019, Sunway Medical Centre, Subang Jaya, Selangor, Malaysia. (Unpublished)

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Abstract

Introduction: The increasing incidence of early onset type 2 diabetes worldwide is worrying. Epigenetics may play a role in the pathophysiology of insulin resistance and glucose intolerance. It is hypothesized that overexpression of angiotensin II type 1 receptor (AGTR1) in pancreas impairs insulin sensitivity and insulin secretion, explaining the improved glycaemic control in diabetic patients on angiotensin receptor blocker. Methylation changes in pancreas may be parallel with peripheral blood. To date, the association between AGTR1 methylation and glycemic control has never been investigated. Therefore, the aim of this study is to investigate the association between AGTR1 promoter methylation level and glycaemic control parameters in non-diabetic young adults. Methods: An observational cross-sectional study involving 240 non-diabetic young adults age 18 to 45 years were conducted in Kuantan, Pahang. Subjects were examined for fasting blood glucose (FBG) level, HBA1c level and DNA methylation of AGTR1 promoter of the peripheral blood using MethyLight TaqMan assay. Bivariate and multivariate analysis was conducted to determine the association. Results: AGTR1 methylation was inversely associated with HBA1c (p=0.012, r=-0.173), but not with FBG (p=0.622). The association between AGTR1 methylation and HBA1c remained significant after adjusting to age and sex (p=0.008, =-2.660). Conclusions: AGTR methylation is inversely associated with HBA1c level in non-diabetic young adults, hence may be involved in the pathogenesis of insulin resistance. AGTR1 gene expression should follow to determine if AGTR1 hypermethylation is associated with lower AGTR gene expression which could explain the association.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	7963/81675
Uncontrolled Keywords:	DNA methylation; glycated haemoglobin A; glucose intolerance; MethyLight assay; young adults
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	04 Aug 2020 14:07
Last Modified:	04 Aug 2020 14:07
URI:	http://irep.iium.edu.my/id/eprint/81675

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