Effect of colloid on acid-base balance during colorectal surgery: balanced (tetraspan) versus non balanced (venofundin) hydroxyethyl starch

Ramly, Nur fariza (2017) Effect of colloid on acid-base balance during colorectal surgery: balanced (tetraspan) versus non balanced (venofundin) hydroxyethyl starch. IIUM Press, Kuala Lumpur, Malaysia. ISBN 978-967-418-715-6

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Abstract

This prospective, randomized, controlled study was carried out to compare the usage of balanced and non balanced hydroxyethyl starch during elective colorectal surgery in term of changes in acid-base balance and renal profile in the immediate and early postoperative period. Thirty informed, consented, adult patients with ASA I-II, undergoing open colorectal surgery with duration of more than three hours were recruited after excluding those with significant cardiac, liver or renal diseases, and those with allergy to the starches. These patients were randomly allocated into two study groups. The Balanced group received an intraoperative fluid regimen that consisted of Hartmann’s solution and balanced 6% hydroxytehyl starch (Tetraspan®). The Non Balanced group were given Hartmann’s solution and saline-based 6% hydroxyethyl starch (Venofundin®). Patients were kept hemodynamically stable and normovolumia throughout the operation by giving boluses of the study fluids as volume replacement therapy. Biochemical indices for acid base balance and renal profile were reviewed at two endpoints: immediately post operation (at 1-hour) and early post operation (at 6-hour). There were no difference at immediate and early post operation respectively, noted in term of base excess (p = 0.733 , p = 0.507 ) , chloride (p = 0.483, p = 0.401), lactate (p = 0.477, p = 0.993), urea (p = 0.244, p = 0.190) and creatinine (p = 0.578, p = 0.323) between both groups.

Item Type:	Book
Additional Information:	6087/79203
Uncontrolled Keywords:	Hydroxyethyl Starch
Subjects:	R Medicine > RD Surgery > RD81 Anesthesiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Dr Nur Fariza Ramly
Date Deposited:	08 Sep 2020 11:43
Last Modified:	08 Sep 2020 11:43
URI:	http://irep.iium.edu.my/id/eprint/79203

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