Electro-hydrodynamic assisted mucoadhesive-floating beads containing black seed oil: development and characterization in-vitro and ex-vivo

Azad, Abul Kalam and Doolaanea, Abd Almonem and Al-Mahmood, Sinan Mohammed Abdullah (2019) Electro-hydrodynamic assisted mucoadhesive-floating beads containing black seed oil: development and characterization in-vitro and ex-vivo. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished)

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Abstract

Background: Black seed oil (BSO) is attracting deep attention by scientific community due to its traditional therapeutic claim and pharmacological potential. Alginate widely used due to its biocompatibility, low cost and being a non-toxic polymer. Objective: The main objective of this study was to develop the BSO loaded mucoadhesive-floating beads with targeted size. Material and methods: BSO oil, alginate, lecithin and calcium chloride was used in this formulation. Electro-hydrodynamic assisted technique was employed to prepare BSO loaded alginate microsphere. The current study deals with the development, optimization, in-vitro characterization and ex-vivo mucoadhesive properties of BSO-loaded alginate beads. Results: The beads % of yield was determined. The optimized beads showed high drug encapsulation efficiency and suitable drug release pattern in simulated intestine media. The mean size and sphericity factor of the beads ranged from 0.75 ± 0.01 to 2.64 ± 0.01 mm and 0.05 ± 0.005 to 0.01 ± 0.00 mm respectively. It found to be dominant by Hixson-Crowell model (R2 = 0.983) with correlation coefficient close to unity over 2 h. The beads showed excellent floating behavior, insight of greater mucoadhesive properties and almost 100% swelling rate over 2 h in buffer media (pH 6.8). Conclusion: The technique for the preparation of beads containing BSO was found to be simple, reproducible, easily controllable, economical and consistent. Besides, the raw materials used for the formulation in this study such as sodium alginate, lecithin, calcium chloride and peppermint oil were cheap and easily available. This new approach to sustainable development goal is going to take a step forward, through a wider contribution to the pharmaceutical sector.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7245/79045
Uncontrolled Keywords:	Black seed oil; alginate; electrodynamic; microencapsulation
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Abd Almonem Doolaanea
Date Deposited:	26 Feb 2020 08:11
Last Modified:	26 Feb 2020 08:11
URI:	http://irep.iium.edu.my/id/eprint/79045

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