Novel method for building ancient recombination landscape using archaic human genomes

Tumian, Afidalina (2020) Novel method for building ancient recombination landscape using archaic human genomes. Project Report. UNSPECIFIED. (Unpublished)

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Abstract

PRDM9 is a human zinc finger (ZF) gene responsible for initiating much or all of human recombination. PRDM9 shows extreme variation in both number and sequence of its ZFs, between species and amongst individuals, across mammals. The commonest PRDM9 allele binds the human hotspot motif, CCNCCNTNNCCNC, but other human alleles bind different targets. The rapid evolution of the PRDM9 ZF array may be a response to escape selfdestructive drive called biased gene conversion (BGC).

Item Type:	Monograph (Project Report)
Additional Information:	4915/78181
Uncontrolled Keywords:	archaic human genomes ; ancient
Subjects:	Q Science > QA Mathematics > QA300 Analysis T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Electrical and Computer Engineering
Depositing User:	Dr Afidalina Tumian
Date Deposited:	11 Mar 2020 14:51
Last Modified:	21 Oct 2020 09:16
URI:	http://irep.iium.edu.my/id/eprint/78181

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