Razali, Khairiah and Abdul Hamid, Azzmer Azzar and Md Zin, Noor Hasniza and Muhamad Bunnori, Noraslinda and Ahmad Yusof @ Hanafi, Hanani and Kamarudin, Kamarul Rahim and Mohamed Rehan, Aisyah (2019) Functional annotation of selected streptococcus pneumoniae hypothetical proteins. Malaysia Journal of Science Health and Technology, 4 (Special Issue, KoSiST 2018). pp. 12-16. E-ISSN 2601-0003
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Abstract
The ability of Streptococcus pneumoniae to induce infection relies on its virulence factor machinery. A previous study has identified essential proteins that might be responsible towards the pathogenicity of S. pneumoniae serotype 2 strain D39. How ever, 39 of them were yet functionally and stru cturally uncharacterized. Thus, by using in silico approach, this study aims to annotate the function and the structure of these unannotated proteins. Initially, all 39 targeted proteins went through primary screening for template availability and pathogen icity. From there, 11 of them were selected and were further analyzed on the basis of their physicochemical, functional and structural categorization using an integrated bioinformatics approach by means of amino acid sequence and stru cture - based analysi s. The obtained data suggested that all targeted proteins showed high possibility to be involved in either cell viability or cell pathogenicity mechanism of the bacterium, with SPD_1333 and SPD_1743 being the two most promising proteins to be further studied. Findings from this study could provide a better understanding of the pathogenic ability of this microorganism and thus, enhance drug development and target identification processes in the aim of improving pneumococcal disease control.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 6771/77102 |
| Uncontrolled Keywords: | Hypothetical proteins; S. pneumoniae strain D39; In silico analysis of protein; Bioinformatics tools ; I n silico analysis of protein; B ioinformatics tools |
| Subjects: | Q Science > Q Science (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology |
| Depositing User: | Dr Noor Hasniza Md Zin |
| Date Deposited: | 01 Jan 2020 00:01 |
| Last Modified: | 08 Apr 2020 12:31 |
| URI: | http://irep.iium.edu.my/id/eprint/77102 |
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