Cryptosporidium-host Interaction alters regulation of oncomiRNAs and tumor suppressor miRNA expression

Başak, Feyza and Jainul, Mohammed Abdullah and Mat Yusof, Afzan (2019) Cryptosporidium-host Interaction alters regulation of oncomiRNAs and tumor suppressor miRNA expression. Journal of Biological Sciences, 19 (4). pp. 272-279. ISSN 1727-3048 E-ISSN 1812-5719

PDF - Published Version Restricted to Registered users only Download (620kB) | Request a copy

Abstract

The apicomplexan parasite Cryptosporidium is well-known for its capability to induce cryptosporidiosis, a severe diarrheal disease in human and animals. Cryptosporidium can also be a potential pathogen in human for cancer progression, particularly colorectal cancer. This review was designed to outline the information about the life cycle of the Cryptosporidium, the consequences of Cryptosporidium infection into the response mechanism in immune compromised host and finally the regulation of oncomiRNAs and tumor suppressor miRNAs upon Cryptosporidium infection. Host-Cryptosporidium interaction caused alteration of expression of a series of microRNAs or miRNAs as a result of controlling defense mechanism. Regulation of miRNAs in the infected cells may be identified as possible biomarkers in cancer progression. Upregulation of oncomicroRNAs or oncomiRNAs and the downregulation of tumor suppressor miRNAs in the host epithelial cells due to the Cryptosporidium infection may lead to cancer initiation on human.

Item Type:	Article (Journal)
Additional Information:	6886/75063
Uncontrolled Keywords:	Cryptosporidium, oncomiRNAs, tumor suppressor,
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing Kulliyyah of Nursing
Depositing User:	Dr. Afzan Mat Yusof
Date Deposited:	30 Oct 2019 11:51
Last Modified:	29 Jun 2020 09:26
URI:	http://irep.iium.edu.my/id/eprint/75063

Actions (login required)

View Item