Fundamental basis of nephropathy in chronic low dose organophosphates exposure

Abdul Razak, Tariq and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Aung, Sanda and Wan Salleh, Wan Muhamad Salahudin (2019) Fundamental basis of nephropathy in chronic low dose organophosphates exposure. Project Report. UNSPECIFIED. (Unpublished)

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Abstract

Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were significant pidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confirmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrificed and the right kidney was subjected to routine H&E examination and specific Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited significant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated.

Item Type:	Monograph (Project Report)
Additional Information:	6299/75053 Project Report
Uncontrolled Keywords:	Organophosphate, nephrotoxicity, pesticides
Subjects:	R Medicine > RC Internal medicine S Agriculture > S Agriculture (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	dr wan muhamad salahudin wan salleh
Date Deposited:	22 Oct 2019 11:57
Last Modified:	22 Oct 2019 11:57
URI:	http://irep.iium.edu.my/id/eprint/75053

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